You and your spouse or you and some other dudes? It matters.
There's been a few threads on this topic and not playing the 9ers, you will have little to worry about. Still, unless you have an abundance of pigmentation, I'd advise you stay away from the area between the airport and Waikiki. There are exceptions, but also the chance of ruining your vacation. Excluding Ala Moana (mall) and the Aloha tower, there's little reason for tourists to be in those areas, including downtown, imo.
Type Honolulu into the search feature at the top. Good stuff in there.
Aloha, e komo mai and Go Hawks.