I would be surprised if he got close to 2500. I would even be mildly surprised if he hit 2106. Even for AP, last year was special, and AP has a lot of tread on his tires.
Last year AP had 6.0 YPC. Think about how stellar Lynch was last year. He had 5.0. MVP Shaun Alexander had 5.1 in 2005. Adrian Peterson's YPC in his previous five seasons? 4.7, 4.6, 4.4, 4.8, 5.6. The 5.6 YPC came from his rookie season where he only had 238 carries. Even for AP, 6.0 is an outlier.
In 2006, Larry Johnson had 416 carries, which is the modern NFL record as best I can tell. Only twice has a back gone over 400 carries. Peterson had 348 carries last season. If AP managed 6.0 yards per carry AND ran the ball 416 times, he'd end up with 2496 yards rushing. So all he'd need to do is have one of the most efficient rushing seasons ever while breaking the carries record.
IMO, it's crazy talk. The likelihood of getting 400+ carries alone is close to zero, and a 6.0 average is similarly rare. There's a reason why Dickerson's record (which is well short of 2500) has lasted so long.