Nothing changes on offense from last game. I suspect if we saw anything new against Carolina that was the ability to open up the middle with seam routes to ZM. That was a great improvement in the game. I also think we see a few fewer out routes as there was another INT on RW to an out receiver. I think we readjust with cover-2 beaters with Rice/Tate and more crossing and inside route patterns to our TE's and Baldwin. The best thing we have going for our offense is they are quite young on D and we can do a lot to help ourselves with a solid running game and exploitative yet conservative passing game (sound familiar?)
On Defense, the tape on our Seahawks reveal just as you said - these smaller receivers will certainly cause trouble when lined up inside/slot because the press coverage by our corners on the outside gives the slot guy a lot of space to work (since they are typically off the LOS and our coverage is usually 5-10 deep there). The nickel/dime guy will have a tough job due the the free release by that slot guy. Also, if in a base D, there's no way our LB's can cover the shifty little guys and still cover Gronk and possibly Hernandez. Hence the reason no outside WR has had a big game in New England for years - just doesn't happen. They have a new running game this year which has not been seen in Tom Brady's career - so it's a bit of a wrinkle that's hard to analyze - however with their record at 3-2, it's encouraging to know their losses came against stingy defenses (Baltimore and Arizona).
I think the matchup favors us slightly - but it is a sure hall of fame QB, a guy who broke the tight end TD record, and a guy who has more receptions than anyone else in football igniting that offense. It will be a very good game for certain and extremely fun to watch.